Expands Life Science Microscopy Portfolio and Adds Mechano-Biology Measurements

BILLERICA, Massachusetts, July 12, 2018 ─ Bruker Corporation today announced that it has acquired JPK Instruments AG (JPK), located in Berlin, Germany. In 2017, JPK Instruments had revenue of approximately 10 million Euro. JPK provides microscopy instrumentation for biomolecular and cellular imaging, as well as force measurements on single molecules, cells and tissues. JPK adds in-depth expertise in live-cell imaging, cellular mechanics, adhesion, and molecular force measurements, optical trapping, and biological stimulus-response characterization to Bruker. Financial details of the transaction were not disclosed.

Over the past five years, Bruker has developed a life science microscopy business that specializes in advanced technologies for neuroscience, live-cell imaging, and molecular imaging, which will be further augmented by JPK’s advanced technologies and applications. Bruker’s existing fluorescence microscopy techniques include performance-leading multiphoton microscopy, swept-field confocal microscopy, super-resolution microscopy, and single-plane illumination microscopy.

“We have been making a substantial investment in advanced technologies for life science imaging, and have built up a portfolio of fluorescence microscopy products that enable biologists in research areas that require deep, fast imaging at high resolution and at low phototoxicity,” commented Dr. Mark R. Munch, President of the Bruker NANO Group. “JPK’s products and applications capabilities nicely augment our current techniques.”

Anthony Finbow, Chairman at JPK, added: “The combination of these two businesses will enable further significant advances in life science imaging and drive the state of the industry. I am delighted that we have been able to achieve this result for JPK and for Bruker.”

“The business we have built aligns well with the new strategic direction of Bruker in life science microscopy, and we are very pleased to join them,” said Dr. Torsten Jaehnke, a JPK founder and CTO. “We plan to realize a number of valuable synergies going forward.”

JPK’s BioAFM and optical tweezer product families span a range of techniques, from imaging of biological samples to characterizing biomolecular and cellular force interactions. Its NanoWizard 4 BioScience AFM combines atomic force imaging with advanced optical fluorescence imaging and super-resolution microscopy for the ultimate combination in image resolution for molecules, membranes, and live cells. In addition, the ForceRobot enables single-molecule force spectroscopy for investigating receptor-ligand interactions or small molecule-protein binding interactions. The CellHesion product brings quantitative force measurement to live cells and tissues, enabling insights in cell-substrate and cell-cell interactions. Lastly, JPK’s NanoTracker optical tweezer provides an all-optical means for molecular and cellular force experiments.

JPK’s offerings and life science applications expertise are synergistic with Bruker’s existing portfolio of advanced fluorescence microscopy products. Bruker’s Ultima family of multiphoton microscopes features proprietary photoactivation and photostimulation capabilities and deeper penetration into biological tissues, enabling advanced brain slice and intra-vital studies. Bruker’s Opterra swept-field scanning confocal fluorescence microscope provides unique live-cell imaging capabilities with unsurpassed dynamic observation of fast cellular events. Additionally, the Vutara super-resolution single-molecule localization (SML) microscope utilizes patented Biplane Imaging technology to provide high-speed, 3D super resolution for multicolor live-cell imaging and visualization of chromosome conformation. With a leading series of single plane illumination products, such as the MuVi SPIM and InVi SPIM, Bruker offers unique performance and easiest-to-use light sheet instruments featuring the combination of low phototoxicity and high-speed imaging. The combined microscopy portfolio of the two companies will enable a unique range of correlative measurements for emerging life science applications.

About Bruker Corporation (NASDAQ: BRKR)

Bruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology.

Investor Contact:
Miroslava Minkova
Director, Investor Relations & Corporate Development
T: +1 (978) 663-3660 x1479
E: miroslava.minkova@bruker.com

Media Contact:
Stephen Hopkins
Bruker Nano Surfaces Content Marketing Manager
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker.com

Infrared Spectroscopy Technology Adds to Bruker’s NanoScale Measurement Portfolio

BILLERICA, Massachusetts, April 17, 2018 ─ Bruker today announced that it has acquired Anasys Instruments Corp., a privately held company that develops and manufactures nanoscale infrared spectroscopy and thermal measurement instruments. This acquisition adds to Bruker’s portfolio of Raman and FTIR spectrometers, as well as to its nanoscale surface science instruments, such as atomic force microscopy and white-light interferometric 3D microscopy. Financial details of the transaction were not disclosed.

Headquartered in Santa Barbara, California, Anasys Instruments Corp. has pioneered the field of nanoprobe-based thermal and infrared measurements. Its industry-leading nanoIR™ products are used by premier academic and industrial scientists and engineers in soft-matter and hard-matter materials science, and in life science applications. Recently Anasys introduced even higher performance with 10 nanometer resolution nanoIR imaging.

“We are very excited to add this strategic, high-growth area to our portfolio of nanoscale microscopy and spectroscopy measurement products,” said Dr. Mark R. Munch, President of the Bruker NANO Group. “There are tremendous application and technology synergies that will benefit our customers.”

“We are very happy to have found a company like Bruker to take the business to the next level,” added Roshan Shetty, co-founder and former CEO of Anasys. “We feel that Bruker’s history in innovative instrument research, and Bruker’s global reach will build on our own history of unique and pioneering achievements in thermal and nanoIR measurements.”

About Anasys Instruments Corp.

Anasys Instruments is the world leader in photothermal IR spectroscopy from the nanoscale to the sub-micron and macro scales. We are dedicated to delivering innovative products and solutions that measure spatially varying physical and chemical properties with nanoscale spatial resolution in a diverse range of fields, including polymers, 2D materials, materials science, life science and micro-electronics industry. Our goal is to provide productive solutions that help researchers clear the path to their next discovery and help industrial companies to solve critical process problems.

About Bruker Corporation

For more than 55 years, Bruker has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels.

In close cooperation with our customers, Bruker is enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, and in microscopy, nano-analysis and industrial applications. In recent years, Bruker has also become a provider of high-performance systems for cell biology, preclinical imaging, clinical phenomics and proteomics research, clinical microbiology, and for molecular pathology research. For more information, please visit: www.bruker.com

Investor Contact: 
Miroslava Minkova
Bruker Head of Investor Relations
3400 East Britannia Drive, Suite 150, Tucson, AZ 85706
T: +1 (978) 663-3660 x1479
E: miroslava.minkova@bruker.com

Media Contact: 
Stephen Hopkins
Bruker Nano Surfaces MarCom Supervisor
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker.com

Introducing Bruker’s new MLCT-BIO and MLCT-BIO-DC probes

Optimized probes for lowest forces in BioAFM imaging and force spectroscopy.

Bruker’s new line of MLCT-BIO and MLCT-BIO-DC probes address a range of BioAFM applications, particularly for live cell imaging and force spectroscopy with:

  • Low spring constants down to 0.01N/m for contact mode and bio force spectroscopy
  • Tip radius and apex angle avoids damage on live cells
  • Nitride tip material suitable for bio adhesion / functionalization studies
  • Biocompatible backside gold coating minimizes interference
  • Tight bend specification ensures wide compatibility with AFMs
  • MLCT-BIO-DC adds unique drift compensation on all levers

The added drift compensation on MLCT-BIO-DC enables maintaining low, constant forces in both, contact mode imaging and ramp-hold experiments where force drift often effectively limits the ability to probe cell viscoelasticity.

  • MLCT-BIO six levers/chip with k from 0.01N/m to 0.6N/m, 10-pack
  • MLCT-BIO-DC six levers/chip with k from 0.01N/m to 0.6N/m, , drift compensated, 10-pack

Probes for Quantitative Modulus Mapping with Dimension Icon

Introducing Bruker’s line of individually precalibrated probes for quantitative nanomechanical mapping with Dimension Icon. These probes address the dominant sources of errors in nanomechanics mapping by providing a controlled 30nm end radius and individually LDV (Laser Dopper Vibrometer) calibrated spring constants. Individual probe parameters are embedded in a QR code for fast and error free transfer into Bruker v9.4 NanoScope real-time software with the QR reader included in the new Bruker PeakForce QNM high accuracy kits.

Choose among a range of spring constants from 0.25 N/m to 200 N/m to address your application:

Sharp Conductive Single Crystal Diamond Probes

Highly conductive Apex Sharp diamond probes, formed by a unique patented process ensure the best possible nanomechanical and electrical performance. These tips are sharper and last longer than any other electrical AFM probe. The conductive diamond coating is highly doped with boron which leads to a macroscopic resistivity of 0.003 – 0.005 Ohm∙cm. Contact resistance is typically 10 kΩ depending on contact radius measured on a silver surface. By using wear-resistant sharp diamond probes the contact size is well characterized and stays constant during mechanical measurements. Quantitative and repeatable measurements for over 24 hours of continuous use have been demonstrated with these probes. A gold reflex coating deposited on the detector side of the cantilever to enhance the reflectance of the laser beam.

Choose among two tip radii and three spring constants to match your application:

– AD-0.5-AS – L=225um, W=50um, k=0.5N.m, f=30kHz, r=10+/-5nm
– AD-2.8-AS – L=225um, W=35um, k=2.8N.m, f=65kHz, r=10+/-5nm
– AD-40-AS – L=225um, W=28um, k=40N.m, f=180kHz, r=10+/-5nm
AD-0.5-SS – L=225um, W=50um, k=0.5N.m, f=30kHz, r<5nm
– AD-2.8-SS – L=225um, W=35um, k=2.8N.m, f=65kHz, r<5nm
– AD-40-SS
– L=225um, W=28um, k=40N.m, f=180kHz, r<5nm

Nanomechanics Probe

These tips are specifically designed for high mechanical loads and scratch testing applications. By using wear-resistant diamond and a broad cone angle the contact size is well characterized and stays constant during repeated mechanical measurements. These probes have demonstrated highly repeatable deep (~100nm) indentations into materials such as fused silica and can image the indents at high resolution in-situ using the same probe. Each cantilever comes individually characterized with both spring constant and tip radius accurately measured, to enable fully quantitative nanomechanical measurements. Each probe comes with a high-resolution SEM image showing the precise tip shape to enable fully quantitative measurements. A gold reflex coating deposited on the detector side of the cantilever to enhance the reflectance of the laser beam.

·         AD-150-NM – L=125um, W=30um, k=150N/m, f=500kHz, r=10+/-5nm

Introducing Bruker’s New High Resolution PeakForce Tapping Probes for any application, air and fluid!

Bruker AFM Probes presents the world’s first family of probes specifically targeted at delivering the highest resolution images in PeakForce Tapping mode, for any application.  We now offer high resolution PeakForce Tapping probe solutions for:

– Biomolecular lattice imaging (PEAKFORCE-HIRS-F-A)
– Single biomolecule imaging (PEAKFORCE-HIRS-F-B)
– Delicate samples in air and fluid (PEAKFORCE-HIRS-SSB)
– General imaging in air (SCANASYST-AIR-HPI-SS)
– High speed imaging (FASTSCAN-D-SS)

 PEAKFORCE-HIRS-F-A

Delivers highest resolution on molecular lattices.
– k = 0.35 N/m
– f = 165 kHz
– Tip radius = 1 nm
– 10 probes

Lattice structure of Bacteriorhodopsin (bR) taken on an inverted optical microscope with BioScope Resolve.  Inset showing a single particle averaging of the bR trimer.  Green circle showing a single lattice defect.  Blue circle showing the lattice substructures. Z scale 0.6 nm.

 

PEAKFORCE-HIRS-F-B

Delivers highest resolution on single biomolecules.
– k = 0.12 N/m
– f = 100 kHz
– Tip radius = 1 nm
– 10 probes

 
Continuous imaging of the DNA double helix obtained while operating on an inverted optical microscope.  Both the major and minor grooves, 2.2 nm and 1.2 nm respectively, are clearly resolved over the entire DNA strand.  150 nm scan size.  Movie playback speed 9x.

 

PEAKFORCE-HIRS-SSB

Delivers highest resolution on delicate samples in air and fluid.
– k = 0.12 N/m
– f = 100 kHz
– Tip radius = 1 nm
– 10 probes

300 nm image showing carbon nanotubes to be aligned with the crystalline structure of a quartz substrate.  Acquired on a Dimension Icon using PeakForce Tapping, with PEAKFORCE-HIRS-SSB probes.

 

SCANASYST-AIR-HPI-SS

Delivers highest resolution for general imaging in air.
– k = 0.25 N/m
– f = 55 kHz
– Tip radius = 1 nm
– 10 probes

300 nm image resolving sharp ridges on a Nioprobe sample.  Acquired on a Dimension Icon using PeakForce Tapping, with SCANASYST-AIR-HPI-SS probes.

 

FASTSCAN-D-SS

Delivers highest resolution for high speed imaging.
– k = 0.25 N/m
– f = 110 kHz (fluid)
– Tip radius = 1 nm
– 10 probes

2

Bruker AFM Probes presents the world’s first family of probes specifically targeted at delivering the highest resolution on bio-samples.  From individually isolated biomolecules to 2D moecular lattices, Bruker now offers a PeakForce-HiRs fluid probe to suit your high resolution needs.

Delivers highest resolution on molecular lattices.
– k = 0.35 N/m
– Tip radius = 1 nm
– 10 probes

Lattice structure of Bacteriorhodopsin (bR) taken on an inverted optical microscope with BioScope Resolve.  Inset showing a single particle averaging of the bR trimer.  Green circle showing a single lattice defect.  Blue circle showing the lattice substructures. Z scale 0.6 nm.

 

Delivers highest resolution on single biomolecules.
– k = 0.12 N/m
– Tip radius = 1 nm
– 10 probes

 
Continuous imaging of the DNA double helix obtained while operating on an inverted optical microscope.  Both the major and minor grooves, 2.2 nm and 1.2 nm respectively, are clearly resolved over the entire DNA strand.  150 nm scan size.  Movie playback speed 9x.

 

December 9, 2015

Dear Valued Contact,

Thank you for your business and engagement with Bruker this past year. We want to call your attention to some important changes in our email addresses for 2016.

Effective January 1, 2016 Bruker email addresses with extension “@bruker-nano.com” will no longer be active.

Our new email extensions “@bruker.com” are active immediately.

Please make note of these changes in your files and correspondence. We will not be able to receive or respond to emails directed to the old addresses.
Below is a chart to assist in identifying the new email addresses.table2Feel free to contact us with any questions.

Best regards,
Bruker Nano Surfaces

E-dispatch-784.inddBruker Introduces New RTESP/RTESPA Silicon AFM Probes
Industry Standard for TappingMode & Non-Contact Imaging Modes

Bruker AFM Probes has introduced an improved version of its popular MPP Line of AFM probes. Bruker’s new line of RTESP/A high quality premium etched silicon probes complements the TESP-V2 range of probes and sets the industry standard for imaging in TappingMode and non-contact mode in air, as well as for force modulation measurements and contact mode imaging.

The new RTESP/A design provides:
• Rotated probe tip for more symmetrical representation of sample features
• Tighter dimensional specifications for improved probe to probe consistency
• Tighter alignment of the tip apex to the cantilever resulting in easier laser positioning over the tip
• Improved probe quality & aesthetics

Bruker middle

Did you know? Bruker offers free probes sample packs. Speak with a probes expert today to find out which sample pack is right for you.
Phone: +1 (800) 715-8440
Email: afmprobeorders@bruker.com

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Bruker Nano Surfaces Division
3601 Calle Tecate Suite C
Camarillo, CA 93012, USA
Tel. +1 (805) 388-3326
productinfo@bruker.com
www.brukerafmprobes.com

All Contents ©2015 Bruker Corporation. All Rights Reserved.

Bruker AFM Probes is pleased to announce our latest probes for our Innova-IRIS system for the highest performance Tip Enhanced Raman spectroscopy (TERS).

The new TERS Probe model number TERS-AFM, is an ideal choice for TERS measurements on the most challenging non-conductive samples. It provides the unique combination of reliability for short time to data and high contrast for outstanding chemical identification with a resolution of

TERS-AFM

This probe requires Innova-IRIS system with the TERS Tuning Fork capability. Current IRIS Innova systems can be upgraded to support this requirement.

For more information, contact your local Bruker representative.