In this joint webinar, Dr. Teddy Huang from Bruker will first review recent AFM applications for solar fuels research (converting sunlight, water, and carbon dioxide into hydrogen and liquid fuels), covering the intrinsic challenges resulting from both the complexity of materials/device characterization and the limitation from general small-sample AFMs, and introducing the recent progress in finding solutions.

In the main part of the webinar, Prof. Fengtao Fan will introduce spatially-resolved surface photovoltage (SPV) microscopy, a five-year technical and applications development in his lab based on a Bruker Dimension Icon AFM. This KPFM-based SPV technique has been used for imaging the transfer dynamics of photocarriers generated by absorbing sunlight, providing fundamental insights and practical guidelines for device designs. Prof Fan will take the popular semiconductor metal oxide photoanodes BiVO4 and TiO2 as examples to demonstrate recent important applications of the SPV microscopic technique in advancing the solar fuels research.

Learn more.

Bruker Announces New PeakForce Deep Trench, Contact Resonance Probes; Expands Adama Line

October 25, 2018 ─ Bruker has recently introduced new and expanded probe families to address AFM industry needs.

PeakForce Deep Trench

Bruker’s new PeakForce Deep Trench (PFDT) series of probes is engineered to provide accurate depth metrology and imaging on the most challenging structures encountered on semiconductor samples and optics, including trenches and pits with aggressive aspect ratios and depths of more than 100nm.

Specifically designed for Dimension Icon, this probe series leverages PeakForce Tapping technology. PeakForce is well known to be ideal for aggressive geometries, such as deep and narrow trenches, because it avoids the air damping and sticking effects that plague approaches based on resonant modes such as Tapping or non-contact. The cantilever shape, spring constant, and resonance frequency of these probes are highly optimized for PeakForce Tapping, and the spike angle is tilt corrected for Dimension Icon. The result is repeatable, accurate metrology with high throughput and long tip life.

Contact Resonance

Bruker is also introducing a range of probes for contact resonance. All of these probes feature a wear-resistant, conductive diamond coating for highest repeatability and resolution. On a Dimension Icon with FASTForce Volume Contact Resonance, these probes have been shown to provide many dozens of images with no measurable wear or change in nanomechanical values. These probes also employ Bruker’s V2 process for the most consistent tip and cantilever shape, further enhancing measurement consistency.

Adama

We have vastly expanded our offering of Adama Innovations diamond probes. Our range now includes sharp and supersharp apex diamond tips for high resolution electrical applications, intermediate radius cone shape tips with outstanding consistency, wide angle tips for highest load mechanical applications, and high aspect ratio pillar tips for the most challenging geometries. All tips feature strong wear resistance, allowing for constant contact size and resolution during long term measurements.

 

In Operando Surface Potential Sensing of Photo-electrochemical Anodes

July 25, 2018 ─ Get the latest solar water splitting research from the Boettcher group at University of Oregon, as well as Bruker’s recent Nanoelectrode probe and Data Cube developments. We start with interfacial charge transfer at the semiconductor-catalyst interface – an issue that is central for solar water splitting yet has been poorly understood. New insights require unique experimental approaches- such as using a nanoelectrode AFM-SECM probe, scanning the surface of at water splitting photoanode, and making local surface potential measurements, in operando. In this presentation, we will discuss fundamental aspects and capabilities of the probes used.

We then show how the technique allows for measurement of the surface potential and thickness-dependent electronic properties of cobalt (oxy)hydroxide phosphate (CoPi). We show that when CoPi is deposited on illuminated photoanodes like hematite (a-Fe2O3), it acts as both a hole collector and an oxygen evolution catalyst. The versatility of the technique is highlighted by comparing surface potentials of CoPi-decorated hematite and bismuth vanadate photoelectrodes. Watch the webinar.

Expands Life Science Microscopy Portfolio and Adds Mechano-Biology Measurements

BILLERICA, Massachusetts, July 12, 2018 ─ Bruker Corporation today announced that it has acquired JPK Instruments AG (JPK), located in Berlin, Germany. In 2017, JPK Instruments had revenue of approximately 10 million Euro. JPK provides microscopy instrumentation for biomolecular and cellular imaging, as well as force measurements on single molecules, cells and tissues. JPK adds in-depth expertise in live-cell imaging, cellular mechanics, adhesion, and molecular force measurements, optical trapping, and biological stimulus-response characterization to Bruker. Financial details of the transaction were not disclosed.

Over the past five years, Bruker has developed a life science microscopy business that specializes in advanced technologies for neuroscience, live-cell imaging, and molecular imaging, which will be further augmented by JPK’s advanced technologies and applications. Bruker’s existing fluorescence microscopy techniques include performance-leading multiphoton microscopy, swept-field confocal microscopy, super-resolution microscopy, and single-plane illumination microscopy.

“We have been making a substantial investment in advanced technologies for life science imaging, and have built up a portfolio of fluorescence microscopy products that enable biologists in research areas that require deep, fast imaging at high resolution and at low phototoxicity,” commented Dr. Mark R. Munch, President of the Bruker NANO Group. “JPK’s products and applications capabilities nicely augment our current techniques.”

Anthony Finbow, Chairman at JPK, added: “The combination of these two businesses will enable further significant advances in life science imaging and drive the state of the industry. I am delighted that we have been able to achieve this result for JPK and for Bruker.”

“The business we have built aligns well with the new strategic direction of Bruker in life science microscopy, and we are very pleased to join them,” said Dr. Torsten Jaehnke, a JPK founder and CTO. “We plan to realize a number of valuable synergies going forward.”

JPK’s BioAFM and optical tweezer product families span a range of techniques, from imaging of biological samples to characterizing biomolecular and cellular force interactions. Its NanoWizard 4 BioScience AFM combines atomic force imaging with advanced optical fluorescence imaging and super-resolution microscopy for the ultimate combination in image resolution for molecules, membranes, and live cells. In addition, the ForceRobot enables single-molecule force spectroscopy for investigating receptor-ligand interactions or small molecule-protein binding interactions. The CellHesion product brings quantitative force measurement to live cells and tissues, enabling insights in cell-substrate and cell-cell interactions. Lastly, JPK’s NanoTracker optical tweezer provides an all-optical means for molecular and cellular force experiments.

JPK’s offerings and life science applications expertise are synergistic with Bruker’s existing portfolio of advanced fluorescence microscopy products. Bruker’s Ultima family of multiphoton microscopes features proprietary photoactivation and photostimulation capabilities and deeper penetration into biological tissues, enabling advanced brain slice and intra-vital studies. Bruker’s Opterra swept-field scanning confocal fluorescence microscope provides unique live-cell imaging capabilities with unsurpassed dynamic observation of fast cellular events. Additionally, the Vutara super-resolution single-molecule localization (SML) microscope utilizes patented Biplane Imaging technology to provide high-speed, 3D super resolution for multicolor live-cell imaging and visualization of chromosome conformation. With a leading series of single plane illumination products, such as the MuVi SPIM and InVi SPIM, Bruker offers unique performance and easiest-to-use light sheet instruments featuring the combination of low phototoxicity and high-speed imaging. The combined microscopy portfolio of the two companies will enable a unique range of correlative measurements for emerging life science applications.

About Bruker Corporation (NASDAQ: BRKR)

Bruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology.

Investor Contact:
Miroslava Minkova
Director, Investor Relations & Corporate Development
T: +1 (978) 663-3660 x1479
E: miroslava.minkova@bruker.com

Media Contact:
Stephen Hopkins
Bruker Nano Surfaces Content Marketing Manager
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker.com

Infrared Spectroscopy Technology Adds to Bruker’s NanoScale Measurement Portfolio

BILLERICA, Massachusetts, April 17, 2018 ─ Bruker today announced that it has acquired Anasys Instruments Corp., a privately held company that develops and manufactures nanoscale infrared spectroscopy and thermal measurement instruments. This acquisition adds to Bruker’s portfolio of Raman and FTIR spectrometers, as well as to its nanoscale surface science instruments, such as atomic force microscopy and white-light interferometric 3D microscopy. Financial details of the transaction were not disclosed.

Headquartered in Santa Barbara, California, Anasys Instruments Corp. has pioneered the field of nanoprobe-based thermal and infrared measurements. Its industry-leading nanoIR™ products are used by premier academic and industrial scientists and engineers in soft-matter and hard-matter materials science, and in life science applications. Recently Anasys introduced even higher performance with 10 nanometer resolution nanoIR imaging.

“We are very excited to add this strategic, high-growth area to our portfolio of nanoscale microscopy and spectroscopy measurement products,” said Dr. Mark R. Munch, President of the Bruker NANO Group. “There are tremendous application and technology synergies that will benefit our customers.”

“We are very happy to have found a company like Bruker to take the business to the next level,” added Roshan Shetty, co-founder and former CEO of Anasys. “We feel that Bruker’s history in innovative instrument research, and Bruker’s global reach will build on our own history of unique and pioneering achievements in thermal and nanoIR measurements.”

About Anasys Instruments Corp.

Anasys Instruments is the world leader in photothermal IR spectroscopy from the nanoscale to the sub-micron and macro scales. We are dedicated to delivering innovative products and solutions that measure spatially varying physical and chemical properties with nanoscale spatial resolution in a diverse range of fields, including polymers, 2D materials, materials science, life science and micro-electronics industry. Our goal is to provide productive solutions that help researchers clear the path to their next discovery and help industrial companies to solve critical process problems.

About Bruker Corporation

For more than 55 years, Bruker has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels.

In close cooperation with our customers, Bruker is enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, and in microscopy, nano-analysis and industrial applications. In recent years, Bruker has also become a provider of high-performance systems for cell biology, preclinical imaging, clinical phenomics and proteomics research, clinical microbiology, and for molecular pathology research. For more information, please visit: www.bruker.com

Investor Contact: 
Miroslava Minkova
Bruker Head of Investor Relations
3400 East Britannia Drive, Suite 150, Tucson, AZ 85706
T: +1 (978) 663-3660 x1479
E: miroslava.minkova@bruker.com

Media Contact: 
Stephen Hopkins
Bruker Nano Surfaces MarCom Supervisor
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker.com

PeakForce Tapping & QNM

Friday, 1 June 2018 Comments (0)  

PeakForce Tapping™ is an AC imaging technique, i.e., the cantilever is oscillated but well below resonance. This results in a continuous series of force-distance curves. In addition to direct force control by keeping the peak force constant, a multitude of material properties can be extracted and quantified from the force-distance curve at each pixel within an image, such as modulus, adhesion force, and deformation depth.

Probes:

 

 

Featuring PeakForce Tapping for Quantitative Bio-Mechanical Property Mapping

 

SAN Diego, California – December 15, 2014 – At the Sixth AFM BioMed Conference, Bruker (NASDAQ: BRKR) today announced the release of BioScope Resolve™, a biological atomic force microscope (bioAFM) that features the highest resolution imaging and most complete cell mechanics capabilities available for use with an inverted optical microscope (IOM). The system incorporates Bruker’s proprietary PeakForce Tapping® technology to enable researchers to achieve both the highest resolution imaging and piconewton level force measurements on biological samples. BioScope Resolve also provides real-time correlation of atomic force microscopy and optical microscopy data sets to provide unique insights into life sciences research. Ultimately, BioScope Resolve enables imaging and mechanical property mapping of the biological detail of cells, tissues, and biomolecular structures never previously observed with a bioAFM on an IOM.

“For the first time bioAFM analysis can directly correlate high-resolution molecular structures with function on the same cell,” said Dr. Lewis Francis of the College of Medicine and Center of NanoHealth at Swansea University, United Kingdom. “BioScope Resolveprovides the dynamic range and resolution necessary to allow a deeper understanding of structure-function relationships at cell and tissue surfaces.”

BioScope Resolve establishes a new benchmark for high-resolution imaging and cell mechanics characterization capabilities that are fully integrated with optical microscopy,” added David V. Rossi, Executive Vice President and General Manager of Bruker’s AFM business. “It builds upon our exclusive and leading PeakForce Tapping technology to enable the highest performance bioAFM that researchers of every experience level will find very easy to use.”

“PeakForce Tapping provided my lab with the force control and resolution necessary to produce ground-breaking ligand-receptor interaction maps using functionalized probes on live cells in a very time efficient and controlled way,” commented Professor Dr. Daniel Muller of the Department of Biosystems Science and Engineering at the ETH Zürich, Switzerland, about his experience using PeakForce Tapping.

About BioScope Resolve

BioScope Resolve is an AFM developed specifically for integration with optical microscopy for biological research into cells, tissues and molecules. The new system provides the most complete range of capabilities for cell mechanics and molecular force spectroscopy. Its design enables the highest resolution imaging for all types of biological samples, from cells to biomolecules, making it the new benchmark in high-resolution bioAFM capability. In addition, BioScope Resolve has complete synchronization with the top inverted optical microscope brands, and provides single-button imaging using proprietary ScanAsyst® technology. Researchers can utilize the system’s quantitative PeakForce QNM® nanomechanics package to map the surfaces of soft biological samples. BioScope Resolve’smechanical mapping capabilities bridge Force Volume and PeakForce QNM frequencies for the widest range available for force-distance curves on any AFM. BioScope Resolve also offers a full array of accessories to preserve the integrity of delicate samples, including carrier support with clear visual and physical access to samples, environmental control with heating and cooling capabilities, and a wide range of pre-calibrated biological probes.

About Bruker Corporation

Bruker Corporation is a leading provider of high-performance scientific instruments and solutions for molecular, cellular and materials research, as well as for industrial, diagnostics, clinical research and applied analysis.

Media Contact: 
Stephen Hopkins, Marketing Communications
Bruker Nano Surfaces Division
3400 East Britannia Drive, Suite 150, Tucson, AZ 85706
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker-nano.com

Investor Contact: 
Joshua Young
Vice President, Investor Relations
T: +1 (978) 663-3660 x1479
E: Joshua.young@bruker.com

World-Leading Graphene Research Facility Purchases Multiple Bruker AFMs

 

BILLERICA, Mass. – April 6, 2015 – Bruker Corporation (NASDAQ: BRKR) today announced an official partnership with the University of Manchester’s National Graphene Institute (NGI), joining a select list of industrial collaborators. This partnership follows NGI’s purchase of two additional atomic force microscopes (AFMs) from Bruker, a Dimension FastScan® and a Dimension Icon®. These systems join five other Bruker AFMs at the facility for research into the nanofabrication and nanoscale properties of graphene. As part of this partnership, Bruker will partially sponsor a Ph.D. student working on novel scanning probe microscopy (SPM) techniques to characterize graphene and 2D materials.

 

Graphene, the world’s thinnest, strongest and most conductive material, was first isolated and characterized at The University of Manchester by Sir Andre Geim and Sir Kostya Novoselov, who were awarded the Nobel Prize for Physics in 2010 for their research. This transparent, one-atom thick flat sheet of carbon has the potential to revolutionize technology, from smartphones and ultrafast broadband to drug delivery and computer chips. AFMs have demonstrated spatial resolution of less than a nanometer, and enable scientists developing materials such as graphene to understand critical mechanical, electrical, and chemical properties at the atomic scale.

 

“Our Bruker AFMs are anticipated to provide important new insights into nanoscale variations of graphene conductivity and work function,” said Nobel Prize winner Professor Novoselov. “Coupled with simultaneous quantitative mapping of mechanical properties, enabled by Bruker’s exclusive PeakForce Tapping®, NGI researchers hope to uncover new information that will ultimately optimize the performance of graphene-based materials and devices.”

 

“We are pleased that the National Graphene Institute continues to rely on our proprietary technology for its new world-class research facility, bringing their total now to seven Bruker systems,” added Paul Scagnetti, Ph.D., President of Bruker’s Nano Surfaces Division. He continued: “We are also gratified to be a part of the UK-wide Centre for Doctoral Training, where our unique AFM technologies will enable the sponsored Ph.D. student to learn even more about the physical and electrical properties of 2D materials under Professor Novoselov.”

 

About the UK National Graphene Institute 
The National Graphene Institute at The University of Manchester, UK, opened in March 2015, creating around 100 new jobs in a new, 7,800 square meter facility that will house state-of-the-art facilities, including two cleanrooms. The Institute will also feature a 1,500 square meter research lab for University of Manchester graphene scientists to collaborate with their colleagues from industry and other universities.

 

About Bruker Corporation 
For more than 50 years, Bruker has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific research instruments and high-value analytical solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels.

 

In close cooperation with our customers, Bruker is enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics.

 

Media Contact: 
Stephen Hopkins, Marketing Communications
Bruker Nano Surfaces Division
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker-nano.com

 

Investor Contact: 
Joshua Young
Vice President, Investor Relations
T: +1 (978) 663-3660 x1479
E: Joshua.young@bruker.com

SANTA BARBARA, California, September 30, 2014 – In a just released article in the Journal of Molecular Recognition, Dr. Hermann Schillers et al. report the first visualization of individual microvilli on living cells with atomic force microscopy. Microvilli are soft, microscopic cellular membrane protrusions present on epithelial cells that act to increase available surface area, enhance transmembrane transport, and serve as mechanosensors. Changes in their density and morphology are associated with diseases, such as celiac disease. As noted by Dr. Schillers, direct observation of microvilli on live cells had long eluded the AFM community.

“It was previously impossible to resolve the finest structures of a live cell like microvilli, but now with the BioScope Resolve, I can image them easily in one hour,” noted Dr. Schillers, lead author of the article. “This opens up exciting opportunities for new studies. Observing the structural and therefore functional integrity of microvilli on living cells will help to understand the development of microvilli-dependent diseases.”

Conventional AFMs subject live cells to high normal and lateral forces, yielding images that are dominated by the structure of the harder, underlying cytoskeleton and thus limiting their ability to track any changes in situ on the membrane of live cells. Bruker’s BioScope Resolve™ overcomes this challenge by probing the cell membrane at lower forces and with less spatial averaging from the extended probe structure and its movement through the viscous medium, bringing soft cell membrane structures into clear view for the first time.

About BioScope Resolve BioScope 
Resolve is an AFM designed specifically for the highest resolution imaging of all biological samples while on the inverted optical microscope. BioScope Resolve is the only AFM to resolve individual microvilli on live cells. It provides the most complete range of capabilities for cell mechanics and molecular force spectroscopy. Its exclusive PeakForce QNM® and FastForce Volume™ techniques deliver the highest resolution and fastest force mapping capabilities possible with an AFM and the widest range of force distance ramp rates. In addition, BioScope Resolve offers complete synchronization of AFM imaging and force spectroscopy with optical microscopy techniques, enabling new kinds of correlated experiments. BioScope Resolve is available with a full array of accessories including temperature and environmental control for live-cell imaging. For more information about Bruker’s BioAFM systems, please visit www.bruker.com/bioafm.

Media Contact: 
Stephen Hopkins, Marketing Communications
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker.com

SANTA BARBARA, California – January 12, 2016 – Bruker’s Nano Surfaces Division today announced the release of the MultiMode 8-HR Atomic Force Microscope (AFM), which brings extensive new capabilities for nanomechanics and higher speed imaging to the world’s highest resolution, most widely-used and field-proven scanning probe microscope (SPM). The new nanomechanics features of MultiMode 8-HR enable researchers to access the broadest range of ramp frequencies for viscoelastic studies and nanomechanical assessment of a wide range of materials, from soft biological specimens to hard metallic samples.

“The MultiMode® platform has long been the gold standard for performance and application versatility, and we’ve significantly enhanced its capabilities with the MultiMode 8-HR,” commented Stephen Minne, Ph.D., Vice President and General Manager of Bruker’s AFM Business. “Unique improvements include higher speeds, higher resolution imaging, new capabilities in nanomechanics with enhanced PeakForce QNM®, and new FastForce Volume™ modes. In keeping with our ongoing commitment to our thousands of loyal MultiMode customers, we have designed these new developments in resolution, flexibility, and reliability to be available also as upgrades to their current MultiMode systems.”

About MultiMode 8-HR 
The high-resolution and data processing capabilities of the MultiMode 8-HR are the result of its combination of rigid, mechanical design and extremely advanced control electronics. Utilizing Bruker’s NanoScope® V Controller and new Version 8.2 software, the system features unprecedented bandwidth and extremely low-noise data acquisition to enable such proprietary technology advances as ScanAsyst®, Peak Force QNM and FastForce Volume. These features combine to reaffirm the MultiMode 8-HR as the most versatile, highest performance AFM in its class.

About Bruker Corporation
For more than 50 years, Bruker has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific research instruments and high-value analytical solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics.

Media Contact: 
Stephen Hopkins, Marketing Communications
Bruker Nano Surfaces Division
T: +1 (520) 741-1044 x1022
E: steve.hopkins@bruker.com